Download: AntipyreticMedications
ANTIPYRETIC
MEDICATIONS
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Detection of fever varies based on the site of body
measurement.
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FEVER THRESHOLDS
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Rectal
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Oral
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Axillary
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Tympanic
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Temporal
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>100.4°F
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>99.7°F
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>99.3°F
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>100.0°F
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0–2 mo.
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>100.7°F
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3–47 mo.
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>100.3°F
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≥4 yrs.
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>100.1°F
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Generic
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Formulation
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Strengths
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Children's Dose
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Adult Dose
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Rx
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Injection
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10mg/mL
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≥2–12yrs: 15mg/kg every 6 hours; 12.5mg/kg every
4 hours
Max: 75mg/kg/day
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<50kg: Same as children's dose.
≥50kg: 1000mg every 6 hours; 650mg every 4 hours
Max 4g/day
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OTC
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Tabs
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325mg, 500mg
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10–15mg/kg every 4–6 hours
Max: 2.6g/day in children <12yrs
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Regular release:
325–650mg every 4–6 hours
Extended release: 1300mg every 8 hours
Max: 4g/day†,§
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Chew tabs
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80mg
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Oral disintegrating tabs
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80mg, 160mg
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Ext-rel tabs
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650mg
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Caps
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500mg
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Liquid/Elixir
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160mg/5mL, 500mg/5mL
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Solution
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160mg/5mL
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Suspension
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160mg/5mL
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Gel Syrup
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160mg/5mL
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Suppository
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80mg, 120mg, 325mg, 650mg
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Packet
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950mg
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OTC
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Tabs
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81mg, 325mg, 500mg
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Not recommended for children ≤15yrs‡
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Oral: 325–650mg every 4–6 hours
Rectal: 300–600mg every 4–6 hours
Max: 4g/day
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Chew tabs
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75mg, 81mg
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Oral disintegrating tabs
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81mg
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Del-rel tabs
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81mg, 162mg, 325mg, 500mg, 650mg
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Caplet
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325mg, 500mg
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Suppository
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60mg, 120mg, 200mg, 300mg, 600mg
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Rx
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Injection
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100mg/mL
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Not recommended
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Initially 400mg, then 400mg every 4–6 hours or 100–200mg
every 4 hours
Max: 3.2g/day
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OTC
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Tabs
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100mg, 200mg
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6mos–12yrs:
Temp <102.5°F (<39°C): 5mg/kg/dose;
Temperature >102.5°F (>39°C): 10mg/kg/dose
every 6–8 hours
Max: 40mg/kg/day
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200–400mg every 4–6 hours
Max: 1.2g/day
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Chew tabs
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100mg
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Caps
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200mg
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Suspension
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100mg/5mL, 40mg/mL, 50mg/1.25mL
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OTC
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Tabs
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220mg
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Not recommended for children <12yrs
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220mg every 8–12 hours
Max: 660mg/day
≥65yrs: 220mg every 12 hours
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Caps
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NOTES
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† Max dose is 3250mg/day for Tylenol brand regular strength
and 3g/day for Tylenol brand extra strength; dosing interval for Tylenol
brand extra strength is every 6 hours.
§ Max dose is 2g/day for patients with poor nutritional
intake, those taking concurrent hepatotoxic medications, or those who drink
three or more alcoholic beverages daily.
‡ Aspirin may be given to children ≤15yrs of age under
physician supervision if influenza or chickenpox can be confidently ruled out
(10–15mg/kg every 4–6hrs, max 5 doses/24hrs).
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Adapted from: Feret BM. Chapter 6.
Fever. In: Krinsky DL, Berardi RR, Ferreri SP, et al, eds. Handbook of Nonprescription Drugs: An Interactive
Approach to Self-Care, 17th Edition. Washington, DC: American
Pharmacists Association; 2012.
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