CLINICAL TOXICOLOGY-PharmD Notes

1.     General principles involved in the management of poisoning

2.    Antidotes and the clinical applications.

3.    Supportive care in clinical Toxicology.

4.    Gut Decontamination.

5.    Elimination Enhancement.

6.    Toxicokinetics.

7.    Clinical symptoms and management of acute poisoning with the following agents –

a) Pesticide poisoning: organophosphorouscompounds, carbamates, organochlorines, pyrethroids.

b)    Opiates overdose.

c)    Antidepressants

d)    Barbiturates and benzodiazepines.

e)    Alcohol: ethanol, methanol.

f)     Paracetamol and salicylates.

g)    Non-steroidal anti-inflammatory drugs.

h)    Hydrocarbons: Petroleum products and PEG.

i)     Caustics: inorganic acids and alkali.

j)     Radiation poisoning

8.    Clinical symptoms and management of chronic poisoning with the following agents –

         Heavy metals: Arsenic, lead, mercury, iron, copper

9.    Venomous snake bites: Families of venomoussnakes, clinical effects of venoms, general management as first aid, early manifestations, complications and snake bite injuries.

10.  Plants poisoning. Mushrooms, Mycotoxins.

11.   Food poisonings

12.  Envenomations – Arthropod bites and stings.

Substance abuse: 

Signs and symptoms of substance abuse and treatment of dependence

a)    CNS stimulants :amphetamine

b)    Opioids

c)    CNS depressants

d)    Hallucinogens: LSD

e)    Cannabis group

f)     Tobacco
    Drug abuse PPT#2

References:

a.    Matthew J Ellenhorn. ELLENHORNS MEDICAL TOXICOLOGY – DIAGNOSIS AND TREATMENT OF POISONING.  Second edition.  Williams and Willkins publication, London

b.    V V Pillay.  HANDBOOK OF FORENSIC MEDICINE AND TOXICOLOGY.  Thirteenth edition 2003 Paras Publication, Hyderabad