Drugs following zero order pharmacokinetics

' Peas & WHEATS '

• Phenytoin, Phenylbutazone
• Warfarin
• Heparin
• Ethanol
• Aspirin
• Theophylline, Tolbutamide
• Salicylates

A Pea would look like a zero and denotes the order.

Pea also stands for ' Pee' ing out a constant amount as in zero order kinetics constant amount of the drug is eliminated per unit time. Rate of elimination is constant and does not depend on or vary with the drug intake or plasma concentration of the drug.

Did you know?

 Very few drugs follow pure zero order pharmacokinetics (non linear pharmacokinetics), e.g.alcohol.
 Any drug at high concentration may show zero order kinetics, when its metabolic or elimintaion pathway is saturated.